It is a component called "glycerophosphocholine" obtained by hydrolyzing soybean lecithin (phospholipid contained in soybean).The scientific name is "sn-glycero (3) phosphocholine".
Overseas, it has been used for medicines and supplements for the purpose of supplementing "choline".
In Japan, it has been approved as a new food ingredient due to the revision of the law.
In addition, it is a safe ingredient that is universally present in the body, including breast milk.

One of the features of α-GPC as a “choline” supplement is that it can efficiently supplement “choline” in a small amount.
Comparing the amount required to ingest "choline", the amount required as α-GPC is 1/4 that of soybean lecithin (PC) expected as a "choline" supplement.
As a "choline" supplement, α-GPC is the most suitable ingredient.

Comparison of the amount needed to take 1g of choline

There are various research reports on the physiological function of α-GPC.

1. Improvement of dementia
2. Improving learning ability
3. Suppression of stress hormone secretion

1. Promotion of growth hormone secretion
2. Improvement of liver dysfunction
3. Blood pressure lowering effect
4. Improving competitive performance
5. Immunity during infection/improvement in injuries

Evaluation of cognitive function in patients with Alzheimer-type dementia

n=261 （Patients with mild to moderate Alzheimer's dementia） Ingest α-GPC 400mg×3 times daily for 180 days

（Clin. Ther., 25(1), 178-93., (2003) Partially modified）

ADAS-Cog：Alzheimer's Disease Assessment Scale-Cognitive Subscale

Improve learning ability

（Neuro sci Lett., 167(1-2), 171-4., (1994)）

Suppression of stress hormone secretion

α-GPC confirmed a decrease in blood levels of cortisol and adrenocorticotropic hormone, which are typical stress hormone markers.

N=19 ( Men and Women over the age of 60)
Intramuscular injection of α-GPC 1,000mg daily for 3 months

（Le Basi Razionali della Terapia., 23(Suppp.3)., 108-116., (1993)）

Growth hormone secretion promotion

N=15 ( 7 young human and 8 elder human)
Intravenous injection of α-GPC 1,000mg + Growth hormone-releasing hormone (GHRH) 1μg/kg

（Horm.metab.Res., 24, 119-121., (1992) Partially modified）

Improvement of liver dysfunction

（FASEB J., 2093-8., (1991)）

It has been confirmed that choline deficiency raises plasma ALT (GPT) concentration, which is one of the typical markers of liver dysfunction.
Taking α-GPC and supplementing with choline may improve liver dysfunction.

Blood pressure lowering effect

（JP S62-111926A）
Magnus tubectomy artery vasorelaxation test

Norepinephrine is secreted during stress and causes peripheral blood vessels to contract. α-GPC relaxes peripheral vasoconstriction induced by norepinephrine, similar to acetylcholine (a tension-relieving substance), and has been confirmed in a test using rat aortic isolated vascular fragments.
Since α-GPC exhibits a vasorelaxant action similar to acetylcholine, it may dilate blood vessels and lower blood pressure.

Expectations for improved atheletic performance

A decrease in plasma choline concentration due to intense exercise has been reported. Ingestion of α-GPC supplements choline and may ameliorate athletic performance deterioration due to decreased plasma choline concentration.

Athletes' plasma choline concentration at the Boston Marathon

（Int.J.Sports Med., 13, S141-S142., (1992)）

Expectations for improving the ability to repair injuries

＊Reference : J Cell Biol., 167(1), 35-41., (2004)

Ingestion of α-GPC may supplement choline, which is one of the constituents of cell membranes, and promote the repair of injured muscle cells.