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| 1. |
Human Primary Skin Irritation Test
Skin irritation closed patch tests were conducted on 51 subjects in good health. No effects on the
skins of all subjects were observed within 24hrs, which means, no primary irritations were
recognized. Moreover, the product was compared with Squalane by conducting skin irritation closed
patch tests on 25 healthy subjects. The results after 72hrs of observation were negative, the same
result as Squalane. No primary irritations were found. |
| 2. |
Human Contact Allergy Test
Allergenic and sensitization effect tests were conducted on 207 subjects in good health in
comparison to Squalane. Closed patch tests on the upper part of the back of each subject were
carried out 10 times during a period of three and a half weeks to observe allergenic reactions.
Furthermore, after a 14-day rest, the 11th application was performed to examine sensitization. On
both examinations, the results after 48hrs showed no allergenic and sensitization effect on human.
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