Policosanol
Docosanol	CH3(CH2)21OH
Tetracosanol	CH3(CH2)23OH
Hexacosanol	CH3(CH2)25OH
Octacosanol	CH3(CH2)27OH
Triacontanol	CH3(CH2)29OH
Dotri Contanol	CH3(CH2)31OH
Tetratriacontanol	CH3(CH2)33OH
Hexatriacontanol	CH3(CH2)35OH

20 adult men, ingestion on policosanol at 16.6mg/day for 4 weeks

Small dense LDL decreased by 9.1% after taking policosanol for 4 weeks (significant difference)

Small dense LDL cholesterol is known to increase in correlation with triglyceride (TG).We think that policosanol affects the suppression of LDL size reduction by suppressing the synthesis of triglyceride.

Expression level of lipid metabolism-related enzymes by DNA microarray

Comparison between control diet group and test diet group supplemented with 1% policosanol

Lipid metabolism-related enzymes

Enzymes related to fatty acid synthesis pathway

FAS	Fatty acid synthase
ACL	ATP-citrate lyase
ME	Malate enzyme
PK	Pyruvate kinase

Enzymes related to triglyceride synthesis

DGAT	Diacylglycerol acyltransferase
MG3PAT	1-acylglycerol-3-phosphate acyltransferase
G3PAT	Glycerol-3-phosphate acyltransferase
DHAPAT	Dihydroxyacetone phosphate acyltransferase

 

12 adult men, ingestion on policosanol at 33mg/day for 6 weeks

Policosanol lowers the liver function markers ( AST, ALT, γ-GTP).

Liver function markers in blood

AST（GOT）	Aspartate aminotransferase
ALT（GPT）	Alanine aminotransferase
γ-GTP	γ-glutamyl transpeptidase

Accelerated decomposition of blood acetaldehyde after drinking

Effects of acetaldehyde: increased heart rate, mood discomfort, vomiting, flushing of the skin