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About -GPC

What's -GPC ?

It is a component called "glycerophosphocholine" obtained by hydrolyzing soybean lecithin (phospholipid contained in soybean).The scientific name is "sn-glycero (3) phosphocholine".
Overseas, it has been used for medicines and supplements for the purpose of supplementing "choline".
In Japan, it has been approved as a new food ingredient due to the revision of the law.
In addition, it is a safe ingredient that is universally present in the body, including breast milk.

-GPC is the best ingredient to supplement "choline"

One of the features of -GPC as a gcholineh supplement is that it can efficiently supplement gcholineh in a small amount.
Comparing the amount required to ingest "choline", the amount required as -GPC is 1/4 that of soybean lecithin (PC) expected as a "choline" supplement.
As a "choline" supplement, -GPC is the most suitable ingredient.

Comparison of the amount needed to take 1g of choline

Comparison of the amount needed to take 1g of choline

Effect of -GPC

There are various research reports on the physiological function of -GPC.

Central action

  1. Improvement of dementia
  2. Improving learning ability
  3. Suppression of stress hormone secretion

Peripheral action

  1. Promotion of growth hormone secretion
  2. Improvement of liver dysfunction
  3. Blood pressure lowering effect
  4. Improving competitive performance
  5. Immunity during infection/improvement in injuries

Central action -1

Evaluation of cognitive function in patients with Alzheimer-type dementia

n=261 iPatients with mild to moderate Alzheimer's dementiaj Ingest -GPC 400mg~3 times daily for 180 days

Improved cognitive performance

iClin. Ther., 25(1), 178-93., (2003) Partially modifiedj

ADAS-CogFAlzheimer's Disease Assessment Scale-Cognitive Subscale

Central action -2

Improve learning ability

In a rat measurement test of discrimination learning ability, it was shown that -GPC improves learning ability.

iNeuro sci Lett., 167(1-2), 171-4., (1994)j

Central action -3

Suppression of stress hormone secretion

-GPC confirmed a decrease in blood levels of cortisol and adrenocorticotropic hormone, which are typical stress hormone markers.

N=19 ( Men and Women over the age of 60)
Intramuscular injection of -GPC 1,000mg daily for 3 months

The amount of stress markers (cortisol, adrenocorticotropic hormone) was reduced.

iLe Basi Razionali della Terapia., 23(Suppp.3)., 108-116., (1993)j

Peripheral action -1

Growth hormone secretion promotion

N=15 ( 7 young human and 8 elder human)
Intravenous injection of -GPC 1,000mg + Growth hormone-releasing hormone (GHRH) 1g/kg

-GPC combined administration increased the growth hormone secretion amount than GHRH (growth hormone-releasing hormone) administration alone. Growth hormone secretion was promoted especially in the elderly.

iHorm.metab.Res., 24, 119-121., (1992) Partially modifiedj

Peripheral action -2

Improvement of liver dysfunction

Improvement of liver dysfunction

iFASEB J., 2093-8., (1991)j

It has been confirmed that choline deficiency raises plasma ALT (GPT) concentration, which is one of the typical markers of liver dysfunction.
Taking -GPC and supplementing with choline may improve liver dysfunction.

Peripheral action -3

Blood pressure lowering effect

Blood pressure lowering effect

iJP S62-111926Aj
Magnus tubectomy artery vasorelaxation test

Norepinephrine is secreted during stress and causes peripheral blood vessels to contract. -GPC relaxes peripheral vasoconstriction induced by norepinephrine, similar to acetylcholine (a tension-relieving substance), and has been confirmed in a test using rat aortic isolated vascular fragments.
Since -GPC exhibits a vasorelaxant action similar to acetylcholine, it may dilate blood vessels and lower blood pressure.

Peripheral action -4

Expectations for improved atheletic performance

A decrease in plasma choline concentration due to intense exercise has been reported.
Ingestion of -GPC supplements choline and may ameliorate athletic performance deterioration due to decreased plasma choline concentration.
Improved atheletic performance

Athletes' plasma choline concentration at the Boston Marathon

Vigorous exercise reduced plasma choline levels.

iInt.J.Sports Med., 13, S141-S142., (1992)j

Peripheral action -5

Expectations for improving the ability to repair injuries

When intense exercise is performed, many muscle cells are damaged (muscle fiber damage), so it is necessary to quickly repair the muscle cells.

Reference : J Cell Biol., 167(1), 35-41., (2004)

Ingestion of -GPC may supplement choline, which is one of the constituents of cell membranes, and promote the repair of injured muscle cells.

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-GPC phosphatidylserine (PS) Policosanol