Policosanol | |
Docosanol | CH3(CH2)21OH |
Tetracosanol | CH3(CH2)23OH |
Hexacosanol | CH3(CH2)25OH |
Octacosanol | CH3(CH2)27OH |
Triacontanol | CH3(CH2)29OH |
Dotri Contanol | CH3(CH2)31OH |
Tetratriacontanol | CH3(CH2)33OH |
Hexatriacontanol | CH3(CH2)35OH |
20 adult men, ingestion on policosanol at 16.6mg/day for 4 weeks
Small dense LDL decreased by 9.1% after taking policosanol for 4 weeks (significant difference)
Small dense LDL cholesterol is known to increase in correlation with triglyceride (TG).We think that policosanol affects the suppression of LDL size reduction by suppressing the synthesis of triglyceride.
Expression level of lipid metabolism-related enzymes by DNA microarray
Comparison between control diet group and test diet group supplemented with 1% policosanol
Lipid metabolism-related enzymes
Enzymes related to fatty acid synthesis pathway
FAS | Fatty acid synthase |
ACL | ATP-citrate lyase |
ME | Malate enzyme |
PK | Pyruvate kinase |
Enzymes related to triglyceride synthesis
DGAT | Diacylglycerol acyltransferase |
MG3PAT | 1-acylglycerol-3-phosphate acyltransferase |
G3PAT | Glycerol-3-phosphate acyltransferase |
DHAPAT | Dihydroxyacetone phosphate acyltransferase |
12 adult men, ingestion on policosanol at 33mg/day for 6 weeks
Policosanol lowers the liver function markers ( AST, ALT, ƒÁ-GTP).
Liver function markers in blood
ASTiGOTj | Aspartate aminotransferase |
ALTiGPTj | Alanine aminotransferase |
ƒÁ-GTP | ƒÁ-glutamyl transpeptidase |
Accelerated decomposition of blood acetaldehyde after drinking
Effects of acetaldehyde: increased heart rate, mood discomfort, vomiting, flushing of the skin
ND: not defected(below the detection limit)